This is one more issue if .NET client applications are trying to hit https endpoint in your Mule 3.8 application, they may get the following error:
The request was aborted; could not create SSL/TLS secure channel
The fix for this issue is to add the following statement:
ServicePointManager.SecurityProtocol = SecurityProtocolType.Tls
| SecurityProtocolType.Tls11
| SecurityProtocolType.Tls12
| SecurityProtocolType.Ssl3;